Building further on previous courses in biomedical ontology, databases and research methods, this course provides an in-depth exploration of the purpose, scope, technical structures & uses of Referent Tracking as a methodology to design information systems that are maximally self-explanatory and explicit in terms of the data they manage and self-aware in terms of their interactions with other systems and users thereof. The course includes theoretical lectures, group discussions and guided exercises, the latter aimed to help integrate all aspects of Referent Tracking into prototype applications useful for the students' PhD thesis work.