This core organic chemistry course introduces reaction mechanisms and organic synthesis to students with varying undergraduate backgrounds in chemistry. Critical skills toward solving mechanism are developed as the underlying organic principles (kinetics, strain, stereoelectronics, stereochemistry and conformational analysis) are elaborated. These principles will be used to predict and understand reactivity and stereochemistry in more sophisticated reactions. Some of the common carbon-carbon bond forming reactions and functional group manipulations are discussed. This course draws on many synthetic examples from the chemical literature to illustrate mechanism, synthetic utility and to exercise predictive skills.