PMY 503 provides graduate students with an in-depth understanding of pharmacological principles plus the ability to use and apply this information. Topics to be included: pharmacokinetic principles (e.g., absorption, distribution, metabolism, excretion, drug dosing); receptor theory and drug-receptor interactions; non-receptor targets (e.g., enzymes, biologics, and RNA-based therapy); pharmacogenetics; drug safety; quantifying drug effects; and target engagement and validation. Each topic will be introduced, and necessary information provided through didactic lectures and active learning sessions. Subsequent interactive sessions will focus on the use and application of this information and will involve a discussion of research articles and research problems using the Socratic Method and quantitative problem-solving. The information provided in this course is the basis for: the therapeutic use of drugs by health care professional; drug development and design by the pharmaceutical and biotech industry; and use of drugs as tools by research scientists.